siRNA

Sugar Modification: 2'-Ome ,  2'-F, etc.

Backbone Modification: PS (phosphorothioate) modification, etc.

E nd modification: Chol (cholesterol), Biotin, Thiol, NH ₂ , etc.

Fluorescent labeling: Cy3, Cy5, etc.

Customized chemical modification and fluorescent labeling proposal design

Antisense  (ASO)

Sugar Modification: 2'-OMe, 2'-MOE, 2'-F, LNA, etc.

Base Modification: methylated cytosine (5-Me-dC), etc.

Backbone Modification: PS (phosphorothioate) modification, etc.

E nd modification: Chol (cholesterol), etc.

Aptamer

Sugar Modification: 2'-OMe, 2'-NH2, 2'-F, LNA, etc.

Base Modification: methylated cytosine (5-Me-dC), etc.

Backbone Modification: PS (phosphorothioate) modification, etc.

E nd modification: 3'-inverted thymidine, Chol (cholesterol), Biotin, Thiol, NH ₂ , fluorescent dyes, etc.

Others

Custom chemical modification and fluorescent labeling services

GalNAc (N-acetylgalactosamine)

GalNAc is the targeting ligand of the sialic acid receptor (ASGPR), which is mainly expressed on the surface of hepatic parenchymal cells. The conjugate of nucleic acid and GalNAc enters the cell through endocytosis to function.

Custom GalNAc Synthesis

GalNAc-siRNA Synthesis

GalNAc-ASO Synthesis

GalNAc-miRNA Synthesis

Customized design and synthesis of GalNAc delivery proposal

Peptide

Peptides have better membrane permeability and strong resistance to degradation. Therefore, conjugating oligonucleotides with various biological functions to peptides can not only improve the biological activity of oligonucleotides but also enhance their cell permeability.

Peptide Synthesis (drug peptides, custom peptides, RGD cyclic peptides, etc.)

Peptide-siRNA Conjugation

Peptide-ASO Conjugation

Peptide-DNA Conjugation

RGD-siRNA Conjugation

Lipid

LNP not only prevents degradation of delivered oligonucleotides and prolongs circulation time, but also facilitates oligonucleotide uptake, enhances intracellular transport, and facilitates endosomal escape.

LNP-siRNA Conjugation

LNP-ASO Conjugation

PEG (polyethylene glycol)

The half-life of PEG-modified ASO in the body is significantly prolonged, and PEG can reduce the excretion rate of oligonucleotides and promote the uptake of nucleic acid drugs by corresponding cells.

PEG-Aptamer Conjugation

PEG-siRNA Conjugation

PEG-ASO Conjugation

Others

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Custom delivery proposal design and synthesis